May 20

For decades, the battle against AIDS followed a forked road: one led researchers to seek ways to stem the transmission, and the other had them trying to treat those with HIV, who are more susceptible. Oddly, it took this long for someone to entertain the idea of doing both.

Anyway, it’s in the works now, and the results are nothing short of impressive. The HIV Prevention Trials Network, an organization funded by the U.S. National Institutes of Health, recently found in a series of trials that a treatment can both suppress HIV levels and stop the patient from passing it on.

The trial, known as HPTN 02, was carried out on 1,763 couples in which one partner was infected with HIV and the other was not. Ninety-seven percent of the respondents were heterosexual, and the remaining 3% were homosexual; they came from 13 sites across Asia, Africa, and North and South America. They were selected in a way that the infected partner did not display enough symptoms to qualify for conventional treatment, partly so that side effects did not cloud the results and partly to avoid spurning drug-resistant strains.

Half of the couples were given conventional treatment following current protocol. The HIV-infected partners were given drugs only if their condition began to develop into AIDS or if their conditions fell below critical levels, measured according to the presence of a particular cell in their blood. Infected partners in the other half were given the drugs right away. All were taught …

written by madamejune

May 03

After a mostly sedentary winter, most of us are flexing our muscles and getting in some much-needed exercise in the spring. Others, however, are working on a different muscle group, if you can call it that: they’re into brain fitness.

Lumosity.com, launched four years ago by San Francisco startup Lumos Labs, works as a “mental gym” by offering daily games and exercises designed to sharpen users’ mental skills. The site now welcomes 2 million visitors per month and has some 12 million members—the number doubled over the past year—and is all set to put brain training on the mainstream market.

The idea first came to Michael Scanlan in 2005, who was then a neuroscience graduate student focusing on the brain’s adaptability to different demands. At the time, mental health was largely concentrated on older generations wanting to fight memory loss. Wondering whether a broader market existed for science-based brain training, he took a leave from grad school and teamed up with Kunal Sarkar and David Drescher on a Web-based training program.

 

It took the trio two years to come up with the right design, exercises, and user experience. But almost instantly after its 2007 launch, Lumosity attracted several venture capitalists and raised over $3 million in funding. Today, it’s one of the fastest-growing sites on the Web, ranking in the top 1,000, according to research group Quantcast.

Lumosity was modeled after fitness clubs, where users pay a monthly fee to access equipment and have their performance tracked. This came …

written by madamejune

Apr 28

Aromatherapy—the use of scents and the sense of smell to create positive psychological or physical reactions—is being incorporated into massage services around the world. Its effects have been known long before modern medicine, but it’s only now that scientists are beginning to understand the processes behind it.

New studies offer clues on how the brain detects and processes odors, and recent research is providing new insights on how this can affect well-being.

A group of researchers in Utah and Colorado are observing odor responses in mice. The four-year study, conducted at the University of Colorado in Denver, shows that smells are first detected in the olfactory bulb before being directed to the brain. Here, it is passed on to the olfactory cortex, which conducts complex analyses of the smell.

The big discovery, however, turned up between the bulb and the cortex. The researchers found that the two parts communicated by sending out a rapid stream of nerve cells. The original idea was that the olfactory bulb filtered the information and the olfactory cortex decided on the smell’s properties, such as whether the source is edible, according to lead researcher Diego Restrepo of the University of Colorado School of Medicine.

As it turns out, information is first processed in the bulb, which sends it to the cortex. What follows is a dialogue between the two organs, after which the brain steps into the picture.

The current use of aromatherapy relies more on essential oils being absorbed through the skin. Combined with …

written by madamejune

Apr 21

Spring is almost in full bloom, and in the West, it’s time to dust off the old running shoes and get some fresh air. Shedding the winter weight is on top of many people’s to-do lists. But with tank top and swimsuit season just weeks away, many are resorting to crash diets. About.com guide Paige Waehner says that easing into a healthy lifestyle is more practical, not to mention more efficient—it will keep you in top form long after summer’s over.

By taking it slow, according to Waehner, one loses fat instead of muscle, which is the way sustainable weight loss should work. Diving straight into intense exercise can slim you down, but not necessarily in the right places.

Waehner says the first step is getting a checkup, especially if you’ve been ill or had an injury over the winter. You’ll want to know if your body is up for a new fitness regimen, and what approach will work best for your condition.

Next, she says, you must commit to 20 minutes to one hour of exercise for four to five days a week. Try to get access to basic equipment such as resistance bands, free weights, or treadmills and elliptical machines. You’ll also need to commit to a healthy diet on most days, if not all.

Cardio is vital to any weight loss program, according to Waehner. Besides burning calories, it conditions your heart and lungs for a range of fitness activities, whether it’s yoga, kick-boxing, or weight lifting. …

written by madamejune

Apr 20

Increasing scrutiny of pharmaceutical companies’ Good Manufacturing Practices (GMP) compliance and US Food and Drug Administration (FDA) oversight of over-the-counter (OTC) drugs and dietary supplements has created a greater demand for high-quality pharmaceutical training and consulting services. NSF-DBA, an NSF International company with more than 25 years of pharmaceutical experience, adds five leading pharmaceutical specialists to provide consulting and in-house training services to help companies comply with international regulations and improve quality management systems:

Ed Arling

A fo…

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Related Links:
NSF-DBA Hires Leading Pharmaceutical specialists to Meet Growing Demand for Training and Consulting
DBA Announces New Name and Logo
International Conference on Counterfeit Medical Products Paves the Way for the MEDICRIME Convention

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written by The Scientist

Apr 10

Fujifilm Diosynth Biotechnologies has been announced as the new name for the former Merck BioManufacturing Network (known as MSD BioManufacturing Network outside the US and Canada) following completion of its acquisition today by FUJIFILM Corporation of Japan.

As previously announced, the acquisition comprises the facilities located in Billingham, UK (MSD Biologics (UK), formerly Avecia Biologics) and Research Triangle Park, NC, US (Diosynth RTP).

Yuzo Toda, general manager of Pharmaceutical Products Division, FUJIFILM Corporation, said: "We are delighted to complete the addition of thi…

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Fujifilm Diosynth Biotechnologies Announced as New Name for MSD BioManufacturing Network
Fujifilm to Acquire MSD BioManufacturing Network
Nuron Biotech Selects Merck BioManufacturing Network as Manufacturing Supplier for NU100

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written by The Scientist

Apr 10

A new paper released by Quanticate provides an overview of some of the ways in which Phase I packages can be tailored to the needs of the specific compound and conducted more efficiently using combination, flexible protocols. It outlines the considerations that need to be made at the planning stage, and how to make best use of emerging PK and safety data to enable informed decisions regarding study progression.

To receive a copy of our new paper, please click on the ‘Flexible Phase I Study Designs’ link at the base of our profile.

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Flexible Phase I Study Designs: Expediting Early Clinical Drug Development
Bayesian Study Design Offers a Pragmatic Solution for Phase II Clinical Development
Quanticate Announces the Rebranding of OPS Search & Selection to Quanticate People

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written by The Scientist

Apr 10

Quanticate has released a free-to-download white paper entitled ‘Bayesian Study Design: The Pragmatic Solution for Phase II Clinical Development’.

Statistically powered studies in phase II clinical development can be large and expensive, and may not be appropriate at a stage in development where much remains unknown about the likely magnitude of benefit of the compound under study. Pilot studies with small sample sizes may be easier and cheaper to run but are unlikely to yield statistically sound results.

An alternative approach, designing such studies in a Bayesian framework, enables cl…

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Related Links:
Flexible Phase I Study Designs: Expediting Early Clinical Drug Development
Bayesian Study Design Offers a Pragmatic Solution for Phase II Clinical Development
Quanticate Announces the Rebranding of OPS Search & Selection to Quanticate People

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written by The Scientist

Apr 10

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include several Pro-VGF-derived peptides, osteoblast activating peptides, and two deuterium-labelled API analogs. A number of products including building blocks for click chemistry and new coupling reagents has also been added to our offer of amino acid derivatives.
Today’s release of 29 new products includes:
Pro-VGF-derived peptides
AQEE-30 and LQEQ-19 have been described to induce penile erection when injected into the pa…

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29 New Products Now Available from Bachem
Six New Products Available from Bachem
Ten New Products Available from Bachem

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written by The Scientist

Apr 10

Fujifilm Corporation and Merck, known as MSD outside the US and Canada, have announced that they have entered into a definitive agreement by which Fujifilm will acquire the Merck BioManufacturing Network, a leading provider of contract manufacturing and development
services for the biopharmaceutical industry and wholly owned by Merck.

"Fujifilm continues to build upon its ongoing commitment to delivering pharmaceutical business," said Shigetaka Komori, president and chief executive officer of Fujifilm Corporation. "This acquisition provides an important addition to our pharmaceutical busin…

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Related Links:
Fujifilm Diosynth Biotechnologies Announced as New Name for MSD BioManufacturing Network
Fujifilm to Acquire MSD BioManufacturing Network
Nuron Biotech Selects Merck BioManufacturing Network as Manufacturing Supplier for NU100

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written by The Scientist